Dose Conversion Between Animals and Humans: A Practical Solution
نویسندگان
چکیده
Abstract: Selecting the most appropriate first-in-human and pharmacologically active dose for any new drugs or biologicals is a crucial step before starting clinical trial investigation in adult healthy human subjects. Extrapolation of between various rodent non-rodent animal species critical biomedical researchers during initial drug development. The objective this review to provide practical guidance on how allometric scaling based body surface area normalization can be effectively utilized conversion species. standard factors are included allow translation animals humans expressed either mg/kg mg/m2. estimation safe important ensure safety tolerability phase-I trials. Keywords: Starting dose, Body area, Dose translation, Human equivalent Animal Interspecies conversion, Allometric scaling... Read more
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ژورنال
عنوان ژورنال: Indian Journal of Pharmaceutical Education and Research
سال: 2022
ISSN: ['0019-5464']
DOI: https://doi.org/10.5530/ijper.56.3.108